Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic.
Identifieur interne : 000279 ( Main/Exploration ); précédent : 000278; suivant : 000280Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic.
Auteurs : Joelle I. Rosser [États-Unis] ; Katharina Röltgen [États-Unis] ; Melissa Dymock [États-Unis] ; John Shepard [États-Unis] ; Andrew Martin [États-Unis] ; Catherine A. Hogan [États-Unis] ; Andra Blomkalns [États-Unis] ; Roshni Mathew [États-Unis] ; Julie Parsonnet [États-Unis] ; Benjamin A. Pinsky [États-Unis] ; Yvonne A. Maldonado [États-Unis] ; Scott D. Boyd [États-Unis] ; Sang-Ick Chang [États-Unis] ; Marisa Holubar [États-Unis]Source :
- Infection control and hospital epidemiology [ 1559-6834 ] ; 2020.
Abstract
OBJECTIVE
We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center.
METHODS
We reviewed anti-severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020.
RESULTS
In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22-3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08-10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47-6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58-2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test.
CONCLUSION
In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.
DOI: 10.1017/ice.2020.1358
PubMed: 33292895
PubMed Central: PMC7783083
Affiliations:
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Rosser</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Dymock, Melissa" sort="Dymock, Melissa" uniqKey="Dymock M" first="Melissa" last="Dymock">Melissa Dymock</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Shepard, John" sort="Shepard, John" uniqKey="Shepard J" first="John" last="Shepard">John Shepard</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Martin, Andrew" sort="Martin, Andrew" uniqKey="Martin A" first="Andrew" last="Martin">Andrew Martin</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Hogan, Catherine A" sort="Hogan, Catherine A" uniqKey="Hogan C" first="Catherine A" last="Hogan">Catherine A. Hogan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Blomkalns, Andra" sort="Blomkalns, Andra" uniqKey="Blomkalns A" first="Andra" last="Blomkalns">Andra Blomkalns</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Emergency Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Mathew, Roshni" sort="Mathew, Roshni" uniqKey="Mathew R" first="Roshni" last="Mathew">Roshni Mathew</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Maldonado, Yvonne A" sort="Maldonado, Yvonne A" uniqKey="Maldonado Y" first="Yvonne A" last="Maldonado">Yvonne A. Maldonado</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Chang, Sang Ick" sort="Chang, Sang Ick" uniqKey="Chang S" first="Sang-Ick" last="Chang">Sang-Ick Chang</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Holubar, Marisa" sort="Holubar, Marisa" uniqKey="Holubar M" first="Marisa" last="Holubar">Marisa Holubar</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33292895</idno><idno type="pmid">33292895</idno><idno type="doi">10.1017/ice.2020.1358</idno><idno type="pmc">PMC7783083</idno><idno type="wicri:Area/Main/Corpus">000116</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000116</idno><idno type="wicri:Area/Main/Curation">000116</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000116</idno><idno type="wicri:Area/Main/Exploration">000116</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic.</title><author><name sortKey="Rosser, Joelle I" sort="Rosser, Joelle I" uniqKey="Rosser J" first="Joelle I" last="Rosser">Joelle I. Rosser</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Dymock, Melissa" sort="Dymock, Melissa" uniqKey="Dymock M" first="Melissa" last="Dymock">Melissa Dymock</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Shepard, John" sort="Shepard, John" uniqKey="Shepard J" first="John" last="Shepard">John Shepard</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Martin, Andrew" sort="Martin, Andrew" uniqKey="Martin A" first="Andrew" last="Martin">Andrew Martin</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Hogan, Catherine A" sort="Hogan, Catherine A" uniqKey="Hogan C" first="Catherine A" last="Hogan">Catherine A. Hogan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Blomkalns, Andra" sort="Blomkalns, Andra" uniqKey="Blomkalns A" first="Andra" last="Blomkalns">Andra Blomkalns</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Emergency Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Mathew, Roshni" sort="Mathew, Roshni" uniqKey="Mathew R" first="Roshni" last="Mathew">Roshni Mathew</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Maldonado, Yvonne A" sort="Maldonado, Yvonne A" uniqKey="Maldonado Y" first="Yvonne A" last="Maldonado">Yvonne A. Maldonado</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Chang, Sang Ick" sort="Chang, Sang Ick" uniqKey="Chang S" first="Sang-Ick" last="Chang">Sang-Ick Chang</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Holubar, Marisa" sort="Holubar, Marisa" uniqKey="Holubar M" first="Marisa" last="Holubar">Marisa Holubar</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Stanford Health Care, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Health Care, Stanford</wicri:cityArea></affiliation></author></analytic><series><title level="j">Infection control and hospital epidemiology</title><idno type="eISSN">1559-6834</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We reviewed anti-severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22-3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08-10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47-6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58-2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33292895</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1559-6834</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Dec</Month><Day>09</Day></PubDate></JournalIssue><Title>Infection control and hospital epidemiology</Title><ISOAbbreviation>Infect Control Hosp Epidemiol</ISOAbbreviation></Journal><ArticleTitle>Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic.</ArticleTitle><Pagination><MedlinePgn>1-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/ice.2020.1358</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We reviewed anti-severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22-3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08-10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47-6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58-2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rosser</LastName><ForeName>Joelle I</ForeName><Initials>JI</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7803-9333</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Röltgen</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dymock</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Stanford Health Care, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shepard</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Stanford Health Care, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Stanford Health Care, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hogan</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blomkalns</LastName><ForeName>Andra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathew</LastName><ForeName>Roshni</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parsonnet</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinsky</LastName><ForeName>Benjamin A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maldonado</LastName><ForeName>Yvonne A</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>Scott D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Sang-Ick</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Stanford Health Care, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holubar</LastName><ForeName>Marisa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Stanford Health Care, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Stanford Healthcare COVID-19 Workforce Response Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Control Hosp Epidemiol</MedlineTA><NlmUniqueID>8804099</NlmUniqueID><ISSNLinking>0899-823X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>N</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>12</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>9</Day><Hour>5</Hour><Minute>48</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33292895</ArticleId><ArticleId IdType="pii">S0899823X20013586</ArticleId><ArticleId IdType="doi">10.1017/ice.2020.1358</ArticleId><ArticleId IdType="pmc">PMC7783083</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Biomed Inform. 2009 Apr;42(2):377-81</Citation><ArticleIdList><ArticleId IdType="pubmed">18929686</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2020 Nov 16;20(1):853</Citation><ArticleIdList><ArticleId IdType="pubmed">33198725</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 19;323(19):1967-1969</Citation><ArticleIdList><ArticleId IdType="pubmed">32250394</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Apr 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Jul;128:104437</Citation><ArticleIdList><ArticleId IdType="pubmed">32434708</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation><ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 2;395(10234):1418-1420</Citation><ArticleIdList><ArticleId IdType="pubmed">32305073</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Rosser, Joelle I" sort="Rosser, Joelle I" uniqKey="Rosser J" first="Joelle I" last="Rosser">Joelle I. Rosser</name></region><name sortKey="Blomkalns, Andra" sort="Blomkalns, Andra" uniqKey="Blomkalns A" first="Andra" last="Blomkalns">Andra Blomkalns</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Chang, Sang Ick" sort="Chang, Sang Ick" uniqKey="Chang S" first="Sang-Ick" last="Chang">Sang-Ick Chang</name><name sortKey="Dymock, Melissa" sort="Dymock, Melissa" uniqKey="Dymock M" first="Melissa" last="Dymock">Melissa Dymock</name><name sortKey="Hogan, Catherine A" sort="Hogan, Catherine A" uniqKey="Hogan C" first="Catherine A" last="Hogan">Catherine A. Hogan</name><name sortKey="Holubar, Marisa" sort="Holubar, Marisa" uniqKey="Holubar M" first="Marisa" last="Holubar">Marisa Holubar</name><name sortKey="Holubar, Marisa" sort="Holubar, Marisa" uniqKey="Holubar M" first="Marisa" last="Holubar">Marisa Holubar</name><name sortKey="Maldonado, Yvonne A" sort="Maldonado, Yvonne A" uniqKey="Maldonado Y" first="Yvonne A" last="Maldonado">Yvonne A. Maldonado</name><name sortKey="Martin, Andrew" sort="Martin, Andrew" uniqKey="Martin A" first="Andrew" last="Martin">Andrew Martin</name><name sortKey="Mathew, Roshni" sort="Mathew, Roshni" uniqKey="Mathew R" first="Roshni" last="Mathew">Roshni Mathew</name><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name><name sortKey="Rosser, Joelle I" sort="Rosser, Joelle I" uniqKey="Rosser J" first="Joelle I" last="Rosser">Joelle I. Rosser</name><name sortKey="Shepard, John" sort="Shepard, John" uniqKey="Shepard J" first="John" last="Shepard">John Shepard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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